Neomycin is primarily indicated in conditions like Decontamination of digestive tract, Hepatic coma, Hepatic encephalopathy, Pre-operative bowel sterilization, Sepsis, Skin infections, Superficial infections, and can also be given in adjunctive therapy as an alternative drug of choice in Acute bacterial enteritis, Bladder infections, Hypercholesterolaemia, Wounds management
Neomycin is contraindicated in conditions like Allergy,Myasthenia gravis,Parkinsonism,Intestinal obstruction,Perforation of eardrum, Renal impairment.
The severe or irreversible adverse effects of Neomycin, which give rise to further complications include Urticaria, Angioneurotic edema, Ototoxicity, Blood dyscrasias, blood dyscrasias.Neomycin produces potentially life-threatening effects which include Anaphylactic shock, Renal failure, Skeletal muscle paralysis, Superinfection. which are responsible for the discontinuation of Neomycin therapy. The signs and symptoms that are produced after the acute overdosage of Neomycin include Permanent deafness. The symptomatic adverse reactions produced by Neomycin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Vertigo, Headache, Diarrhea, Tinnitus, Pruritus, Lethargy, Skin rash, Contact dermatitis, Pyuria, Steatorrhea, Azotemia, Cylindruria, Contact dermatitis.
Neomycin should be used with caution in patients who are sensitive to aminoglycosides, renal disease or renal impairment, patients with dehydration and in elderly patients. Patient with pre-existing tinnitus, vertigo or subclinical high frequency hearing impairrment should be closely monitored for sign of ototoxicity during therapy with neomycin. Take appropriate measures in case of secondary infections. Parenteral use of neomycin or its use for irrigation of wound or serouse cartities is no longer recommended.