Climen Tablets is primarily indicated in conditions like Androgenic acne, Androgenic alopecia, Flare with initial gonadorelin therapy, Hirsutism, Idiopathic precocious puberty, Inoperable prostatic carcinomag Male hypersexuality, Male-female transsexualism, Prostate cancer (metastatic), flare with initial gonadorelin therapy, Prostate cancer (metastatic), hot flushes with gonadorelin therapy, Prostate cancer (metastatic), longterm palliative therapy, Prostate cancer, flare with initial gonadorelin therapy, Prostate cancer, hot flushes with gonadorelin therapy, Prostate cancer, long-term palliative therapy, Prostatic cancer.
Climen Tablets is contraindicated in conditions like Sickle cell anaemia,Liver diseases, Thromboembolism, Chronic depression.
The severe or irreversible adverse effects of Climen Tablets, which give rise to further complications include Azoospermiag Oligozoospermia. Climen Tablets produces potentially life-threatening effects which include Jaundice, Hepatic failure, which are responsible for the discontinuation of Climen Tablets therapy. The symptomatic adverse reactions produced by Climen Tablets are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Fatigue, Gynecomastia, Decreased libido, Decreased LH, Decreased FSH, Increased prolacting Negative nitrogen balance, Increased plasma triglycerides, Fall in fasting plasma glucose, Decreased LDL concentrations.
Avoid cyproterone in patients with liver disease or malignant or wasting disease, chronic depression, severe diabetes with vascular disease, sickle cell anemia or those with history of thrombo-embolic disorders. It should not be given to immature youths. In men treated with cyproterone, liver function should be monitored before treatment, if any sign or symptoms of hepatotoxicity occur then the treatment should be with drawn. In men with prostate cancer, it may be advisable to limit the duration of treatment. It should be used with caution during pregnancy.